Research Internship: Targeted Radionuclide Therapy in Triple-negative Breast Cancer

Introduction

Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes, characterized by poor prognosis, high recurrence rates, and limited treatment options. The lack of hormone receptors and HER2 expression limits the use of established targeted therapies, while resistance to conventional treatments remains a major clinical challenge. These limitations highlight the need for novel therapeutic strategies for patients with aggressive and treatment-resistant TNBC. 

Targeted radionuclide therapy (TRT) has emerged as a promising therapeutic approach by selectively delivering ionizing radiation to tumor cells through tumor-targeting molecules. By combining tumor-specific targeting with localized radiation delivery, TRT may offer an alternative strategy to overcome some limitations of conventional systemic therapies and improve treatment of aggressive tumors, such as TNBC. 

Project description

• The student will perform tumor sample sectioning and immunohistochemical stainings for relevant markers associated with DNA damage, proliferation, and apoptosis. 
• The student will perform cell culture experiments. 
• The project will also involve in vivo work, including mouse inoculation and monitoring of tumor growth through regular tumor volume measurements. 

A candidate has already been selected for this project.